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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. For epidemiological tracking and outbreak investigations of Clostridioides difficile infection (CDI), which molecular typing method based on PCR amplification targeting repetitive elements within the pathogenicity locus (PaLoc) has historically been widely used and designated by specific nomenclature (e.g., NAP1/BI
/027)?

A) Pulsed-field gel electrophoresis (PFGE)
B) PCR Ribotyping
C) Multilocus sequence typing (MLST)
D) Whole-genome sequencing (WGS) SNP analysis

2. A clinical microbiology laboratory is investigating an outbreak of vancomycin-resistantEnterococcus faecium (VRE) in a hospital. Whole-genome sequencing of isolates from different patients reveals the presence of the vanA operon on a mobile genetic element that is highly conserved across all isolates. This finding MOST strongly suggests:

A) Independent acquisition of vancomycin resistance by different E. faecium strains.
B) Horizontal transfer of the vanA operon to multiple susceptible E. faecium strains.
C) Selection of vancomycin-resistant mutants within a susceptible E. faecium population due to antibiotic pressure.
D) Clonal spread of a single VRE strain carrying the vanA operon.

3. A patient develops a febrile illness with jaundice and dark urine after receiving a blood transfusion.
Laboratory testing reveals an elevated level of unconjugated bilirubin and a positive direct Coombs test.
Serological testing is positive for antibodies against a protozoan parasite that infects erythrocytes. The MOST likely causative agent is:

A) Plasmodium falciparum
B) Trypanosoma cruzi
C) Toxoplasma gondii
D) Babesia microti

4. A research laboratory is investigating the mechanism of action of a novel antiviral compound that inhibits the replication of a specific RNA virus. They find that the compound binds directly to the viral RNA-dependent RNA polymerase, preventing its elongation activity. This mechanism is most similar to that of:

A) Oseltamivir
B) Acyclovir
C) Interferon-beta
D) Ribavirin

5. A patient with AIDS develops a disseminated fungal infection. Blood cultures grow a yeast that produces pseudohyphae and terminal chlamydospores on cornmeal agar. The patient's CD4+ T-cell count is below 50 cells/µL. The MOST likely causative organism is:

A) Cryptococcus neoformans
B) Candida albicans
C) Aspergillus fumigatus
D) Pneumocystis jirovecii

Solutions: