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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E2A Expedited Reporting
  • 2. E11 Pediatric Trials
  • 3. E6(R2)/E6(R3) Good Clinical Practice
  • 4. E8 General Considerations for Clinical Trials
  • 5. E9 Statistical Principles
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
Topic 2: Data Management and Informatics17%- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
Topic 3: Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
Topic 4: Study Design and Conduct17%- Study planning
  • 1. Sample size and statistical considerations
  • 2. Study population and eligibility criteria
  • 3. Protocol development and amendments
- Study implementation
  • 1. Study monitoring and oversight
  • 2. Site selection and activation
  • 3. Investigational product management
Topic 5: Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Clinical care and management of research participants
  • 1. Informed consent development and review
  • 2. Continuity of medical care
  • 3. Standard of care vs protocol requirements
- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
Topic 6: Clinical Study Operations15%- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management

ACRP Certified Professional Sample Questions:

Question 1

A sponsor wants a new clinical trial to be reviewed at regular intervals for progress, safety, and endpoint evaluation, and make recommendations to continue, modify, or stop the trial. How should they proceed?

A. Conduct routine investigators' meetings
B. Develop a monitoring plan
C. Draft a CAPA plan
D. Establish a DSMB/IDMC


Question 2

Which of the following would the sponsor need to do FIRST to set up an effective clinical trial quality management system (QMS)?

A. Perform a periodic review to see if the quality methods are effective and relevant.
B. Determine the quality tolerance limits for data transcription errors.
C. Train the research coordinator on the required study assessments schedule.
D. Identify critical processes and data during protocol development.


Question 3

Which statement does NOT represent a study monitor's responsibilities?

A. Report serious adverse events to the IRB/IEC.
B. Verify that the PI has adequate qualifications and resources to conduct the study.
C. Provide communication between the sponsor and the PI.
D. Check the accuracy and completeness of case report forms with source documents.


Question 4

Access to study documentation for auditors and inspectors during an audit or inspection at a clinical trial site is the responsibility of the:

A. CRA
B. CRC
C. Sponsor
D. PI


Question 5

A root cause analysis should be:

A. Written by the investigator.
B. Validated before use in a CAPA.
C. Focused on issues of non-compliance.
D. Specific to a clinical trial.


Solutions:

Question 1
Answer: D
Question 2
Answer: D
Question 3
Answer: A
Question 4
Answer: D
Question 5
Answer: C

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